Office Hours: MWF 10-12 noon in BME 5.202O or by appointment

Research Focus

Zhang Laboratory is developing integrated photonic microsystems, semiconductor chips and nanotechnologies for imaging, sensing and regulating cellular processes critical to healthcare, environmental and defense applications. Current research focuses on developing tools and methods to understand and regulate complex biological networks critical to development and disease, and developing nano-micro fabricated photonic sensors for biomaterials characterization, fast pre-cancer detection and diagnosis. Nano-Micro scale science, Information, and Biomedicine are integrative components of Zhang's research that are used with advanced engineering tools to facilitate biomedical studies and develop point-of-care diagnostics for global health initiatives.

Research Interests   

  • Micro-electro-mechanical Systems (MEMS), Semiconductors and Nanomaterials
  • Micro-optical endoscopes for pre-cancer detections, nanophotonics
  • Biosensors, implantable medical devices

  Selected Publications  

  • K. Hoshino, A. Gopal, M. S. Glaz, D. A. Vanden Bout, and X. J. Zhang, Nanoscale fluorescence imaging with quantum dot near-field electroluminescence, Applied Physics Letters, 101, 043118, 2012.
  • Y. Lee, K. Hoshino, A. Alu, X.J. Zhang, Efficient directional beaming from small apertures using surface-plasmon diffraction gratings, Applied Physics Letters, 101, 041102, 2012.
  • K. Hoshino, P. Cheng, Y. Huang and X.J. Zhang, Computational analysis of immunomagnetic rare cell separation from a particulate blood flow, Analytical Chemistry, 84, 4292-4299, 2012.
  • Y. Wang, M. Raj, G. Bhave, B. Yang, S. McGuff, T. Shen and X.J. Zhang, Portable oral cancer detection using miniature confocal imaging probe with large field of view, Journal of Micromechanics and Microengineering, 22, 065001, 2012.
  • Y. Wang, K. Kumar, L. Wang, X.J. Zhang, Monolithic integration of binary-phase fresnel zone plate objectives on 2-axis scanning micromirrors for compact microscopes, Optical Express, 20, 6, pp.6657-6668, 2012
  • J. Uhr, M. Huebschman, E.P. Frenkel, N. Lane, H. Liu, D. Rana, L. Cheng, A. Lin, G.A. Hughes, X. J. Zhang, and H. G. Garner, Molecular Profiling of Individual Tumor Cells by Hyperspectral Microscopic Imaging, Translational Research – The Journal of Laboratory and Clinical Medicine, 159 (2012), pp. 366-375.
  • T. Sharma, S. Je, B. Gill, X.J. Zhang, Patterning piezoelectric thin film PVDF TrFE based pressure sensor for catheter application, Sensors & Actuators, A Physical, 177, 87–92, 2012.
  • Y. Lee, A. Alu, X.J. Zhang, Efficient Apertureless Scanning Probes Using Patterned Plasmonic Surfaces, Optical Express, Vol. 19, No. 27, pp. 25990-25999, 2011.
  • K. Hoshino, Y.Y. Huang, N. Lane, M. Huebschman, J.W. Uhr, E.P. Frenkel and X.J. Zhang, Microchip based Immunomagnetic Detection of Circulating Tumor Cell, Lab on Chip, 11, 3449-3457, 2011.
  • T. Sharma, Y.Hu, M. Stoller, K. Lin, M. Feldman, R.S. Ruoff, M. Ferrari and X.J. Zhang, Mesoporous Silica Membrane for Ultra-thin Implantable Biofuel Cells, Lab on Chip.2011, 11(14), 2460-2465
  • L. Wang, K. Hoshino, X.J. Zhang, Near field sub-wavelength light focusing via slotted Fabry-Pérot photonic crystal with low in-plane index contrast, Optics Letters, Vol. 36, 10, 1917-1919, 2011
  • Y. Hu, A. Gopal, K. Lin, Y. Peng, X. J. Zhang, M. Ferrari, Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip, Biomicrofluidics, 5, 013410, 2011
  • Y. Wang, S. Bish, J. Tunnell, X.J. Zhang, MEMS Scanner Enabled Real-Time Depth Sensitive Hyperspectral Imaging of Biological Tissue, Optical Express, 18, 23, 2010.
  • K. Karthik, R. Avritscher, D.C. Madoff, T. K. Yu, and X.J. Zhang, Handheld Histology-Equivalent Sectioning Laser-Scanning Confocal Optical Microscope for Interventional Imaging, Biomedical Microdevices, 12, 223-233, 2010