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ABSTRACT:

Aging, the predominant risk factor for numerous chronic diseases, impacts musculoskeletal integrity through complex, multifactorial mechanisms. At the BioMATTER Lab, we integrate biomaterials, 3D biomanufacturing, and mechanobiology to develop innovative treatment strategies for age-related conditions like bone loss and intervertebral disc degeneration. This talk will start with an overview of my research program, followed by insights into our latest work on cellular senescence in the bone microenvironment. Specifically, we explore a crucial, yet unanswered question: How do local versus systemic senescent cells (SnCs) and their secretory phenotypes (SASPs) influence the osteocyte mechanobiology? Our findings open new perspectives on using cellular mechanics as therapeutic targets in skeletal tissue degeneration, highlighting innovative approaches to rejuvenate aging tissue matrices.

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