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ABSTRACT:

Most eukaryotic cells are polarized; they exhibit an asymmetric distribution of molecules, activities, organelles and/or developmental potential within the cell. Cell polarity is crucial for the development, organization, and function of animal tissues. In animals, proteins of the PAR (partitioning) system establish polarity by forming distinct domains on the cell cortex. Our group is interested in the basic mechanisms by which PAR proteins establish distinct cortical domains, how polarity is regulated and coordinated within a tissue, and how polarity mechanisms are modulated across development and evolution. We are addressing these questions using novel single-cell, single-molecule approaches for in vivo biochemistry, in combination with genetic and cell biological studies of living embryos. 

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