Seminars

Abstract: The extracellular matrix (ECM) is primarily composed of fibrous proteins such as collagen, elastin, and fibronectin, which form a supportive fiber meshwork. When cells are in contact with ECM fibers, their cylindrical geometry can induce membrane wrapping and the formation of local curvatures. We found that these membrane curvatures promote the formation of a new type of integrin-mediated cell adhesions – curved adhesions. Curved adhesions are molecularly distinct from focal adhesions and are prevalent in soft fiber matrices in 3D. The balance of focal adhesions and curved adhesions are dependent on the stiffness and the topography of ECM. The findings illustrate the molecular basis for mechanotransduction in different extracellular environments. They also open up new frontiers for drug discovery.

PRESENTER INFORMATION